Independent research in longevity intervention sequencing. Treating aging as an engineering problem.
Explore ResearchA Complete Medical Reference for Biological Age Reversal
The first systematic framework for treating aging as an engineering problem. The Bio-Energetic Sequencing Model: NAD+ restoration, autophagy induction, senolytic clearance, regeneration support, epigenetic stabilization.
Learn MoreThe dominant "stacking" approach fails due to cellular energy bottlenecks. This paper establishes a three-phase "Energy-First" protocol that respects the metabolic constraints of aged cells.
How sequential dosing resolves rapamycin's contradictions. The mTOR inhibitor that suppresses protein synthesis paradoxically improves muscle function when administered to prepared tissues.
Senolytics kill senescent cells—but killing is only half the problem. Why unprepared tissues experience inflammatory overload while prepared tissues achieve genuine rejuvenation.
Formal proof of the Bio-Energetic Sequencing Model. State variables E, C, S, R, P with gating functions, biomarker thresholds, and the dependency graph that makes intervention order mathematically necessary.
Phase 4 introduces stem cell therapy into terrain cleared of senescent cells. Phase 5 explores partial epigenetic reprogramming through OSK factors (not c-Myc).
In ReviewMaster the foundation of the Energy-First protocol. NMN vs NR, optimal dosing, safety considerations, and top brands for 2025.
Download Free PDFEach intervention builds on the previous phase. Order matters.