Independent Research Initiative

Cellular
Rejuvenation
Research

Evidence-based investigation into biological age reversal through intervention sequencing. Why order matters more than compounds.

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Reference Text

Primary Resource
Featured

The Cellular Rejuvenation Protocol

A Systems-Level Framework for Biological Age Reversal

Comprehensive reference covering the Bio-Energetic Sequencing Model: intervention dependency mapping, phase-specific protocols, biomarker targets, and completion criteria. Designed for practitioners, researchers, and advanced readers requiring mechanistic depth.

Scope
286 pages, 33 chapters
Version
First Edition, Dec 2025
Format
PDF (immediate)
Audience
Practitioners
  • Phase Map
  • Biomarkers
  • Completion Criteria
  • Practitioner Checklists
View Details $149

Published Research

3 Articles
· 12 min read Published

The dominant "stacking" approach to longevity fails due to cellular energy bottlenecks. This paper establishes a three-phase protocol: NAD+ restoration, autophagy induction, senolytic clearance.

NAD+ Autophagy Senolytics
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· 10 min read Published

How sequential dosing resolves mTOR inhibition contradictions for muscle and immune function. The compound that suppresses protein synthesis paradoxically improves both when administered to prepared tissues.

Rapamycin mTOR Immunity
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· 11 min read Published

Senolytics kill senescent cells—but killing is only half the problem. Why unprepared tissues experience inflammatory overload while prepared tissues achieve genuine rejuvenation.

Senolytics Fisetin Clearance
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Forthcoming · 2025 In Progress

The Extended Protocol: Stem Cells and Cellular Reprogramming

Phase 4 introduces stem cell therapy into terrain cleared of senescent cells. Phase 5 explores partial epigenetic reprogramming through transient Yamanaka factor expression.

Stem Cells Yamanaka Reprogramming

The Framework

Five Phases

  1. Energy

    NAD+ restoration

  2. Cleanup

    Autophagy induction

  3. Removal

    Senolytic clearance

  4. Regeneration

    Stem cell support

  5. Stabilization

    Epigenetic maintenance

Read Full Methodology

Educational Content Only

This site publishes independent research for educational purposes only. Content has not been evaluated by regulatory authorities and does not constitute medical advice. The interventions discussed involve experimental compounds and protocols. Consult qualified healthcare professionals before considering any intervention.